Serie A Matchweek 21 of the 2025/26 season (January 16–18) arrives in a compact window where rotation, freshness, and tactical discipline can be decisive. With big teams trying to keep pace at the top and mid-table sides pushing for European spots, game control and efficiency in both boxes should make the difference. Expect several matches to be shaped by tempo changes, set pieces, and how well teams manage pressure in the final 20 minutes. This game forms part of the complete Serie A predictions for the matchweek, placing individual fixtures into a broader league framework.
Table of Contents
:
:
vs 
Pisa vs Atalanta
Pisa is currently in 19th place with 13 points and is in a serious fight for survival. After playing 20 matches, they have one win, 10 draws, and 9 losses, with a goal difference of 15:30, indicating major issues in scoring and limited offensive ability. Their form is weak, with few positive results and struggles to maintain leads or rhythm throughout the match.
Offensively, Pisa plays cautiously and creates few chances from open play, while their defense is often under constant pressure and makes mistakes in the final stages of plays. Moreo and Nzola are the most effective forwards, with Tramoni as an additional option, but they lack sufficient support from the midfield. At home, they have one win, three draws, and 6 losses in 10 matches, with a goal difference of 10:19, which does not provide a significant advantage. Their style of play is defensive and reactive.
Atalanta is currently in 7th place with 31 points and is having a solid season with a noticeable intensity. After playing 20 matches, they have 8 wins, 7 draws, and 5 losses, with a goal difference of 25:19, showing a balanced approach between offense and defense. Their form is good, with several consecutive wins and strong performances.
Offensively, Atalanta plays aggressively, using high pressing, quick transitions, and constant pressure in the opponent’s half, while their defense operates in an organized and compact manner. Scamacca is the main attacking threat, with Krstovic and De Ketelaere providing key support. Away from home, they have three wins, three draws, and three losses in 9 matches, with a goal difference of 11:10. Their style is intense and tactically clear.
Pisa will try to defend deep and slow down the pace, while Atalanta will impose their dynamics and maintain continuous pressure. We expect the guests to dominate.
2 (Atalanta to Win)
Predicted CS: 0:2
:
:
vs 
Udinese vs Inter
Udinese is currently in 10th place with 26 points and is having a decent season, but they lack clear consistency. After playing 20 matches, they have 7 wins, 5 draws, and 8 losses, with a goal difference of 22:32, which shows they have limited offense and defensive weaknesses over longer stretches. Their form is inconsistent, with draws and narrow wins, but also losses against better-organized teams.
Offensively, Udinese relies on direct play and physical strength, but they often struggle to create chances from positional attacks, while their defense can falter under continuous pressure. Davis and Zaniolo are the most dangerous players up front, with Ekelenkamp providing support from the midfield. At home, they have three wins, four draws, and three losses in 10 matches, with a goal difference of 11:15, indicating moderate stability. Their style of play is physical and reactive.
Inter is at the top of the table with 46 points and is having the most consistent season in the league, but they can’t afford to make mistakes since AC Milan is just three points behind. After playing 20 matches, they have 15 wins, 4 draws, and 4 losses, with an impressive goal difference of 43:17, showing their dominance in both phases of the game. Their form is excellent, with a winning streak and high control over the matches.
Offensively, Inter plays in an organized and efficient way, with quick ball movement and quality finishing, while their defense is the most reliable in the league, rarely allowing clear chances. Lautaro Martinez is the main threat, with Calhanoglu and Thuram as key players. On the road, they have 7 wins and 2 losses in 9 matches, with a goal difference of 16:9. Their style is controlled, mature, and results-oriented.
Udinese will defend deeply and look for chances from set pieces, while Inter will control the game through possession and patient pressure. A match dominated by the visitors is expected, with limited chances for the home team.
2 (Inter to Win)
Predicted CS: 0:1
:
:
vs 
Napoli vs Sassuolo
Napoli is currently in 3rd place with 40 points and is having a solid season, clearly fighting for the top spot. After playing 20 matches, they have 12 wins, 4 draws, and 4 losses, with a goal difference of 30:17, showing a good balance between offense and defense. Their form is strong, with a series of matches without a loss and a controlled approach in most of their games.
Offensively, Napoli plays patiently and organized, building up their attacks gradually and finishing well, while their defense is compact and disciplined. Hojlund is the most dangerous option in attack, with McTominay and Anguissa being key players in the midfield. At home, they have 6 wins and 3 draws in 9 matches, remaining unbeaten, with a goal difference of 16:8, which gives them a clear advantage. Their style of play is controlled, focusing on possession and tactical stability.
Sassuolo is currently in 11th place with 23 points and has had a season full of ups and downs. After playing 20 matches, they have 6 wins, 5 draws, and 9 losses, with a goal difference of 23:27, showing their instability, especially in defense. Their form has been negative, with more losses in recent games and struggles to maintain results.
Offensively, Sassuolo relies on individual talent and quick attacks, but they often face issues in organization against stronger teams, while their defense leaves gaps between the lines. Berardi is a key player and leader, with Pinamonti and Lauriente providing support in finishing. Away from home, they have three wins, three draws, and 4 losses in 10 matches, with a goal difference of 12:13. Their style of play is offensively oriented but risky.
Napoli will control the game through possession and tempo, while Sassuolo will look for chances from transitions and individual plays. A match dominated by the home team is expected, and finally, Napoli should secure all three points after three draws.
1 (Napoli to Win)
Predicted CS: 1:0
:
:
vs 
Cagliari vs Juventus
Cagliari is currently in 16th place with 19 points and is fighting hard to stay in the league. After playing 20 matches, they have 4 wins, 7 draws, and 9 losses, with a goal difference of 21:30, which shows they have issues with defensive stability and lack effectiveness in crucial moments. Their form is inconsistent, with draws and occasional wins at home, but also losses against stronger opponents.
Offensively, Cagliari relies on direct play and individual solutions, but they struggle to maintain continuous pressure, while their defense often breaks under intensity. Esposito is the most effective forward, with Borrelli and Gaetano providing support. At home, they have two wins, three draws, and 4 losses in 9 matches, with a goal difference of 10:13. Their style is combative and reactive.
Juventus is currently in 4th place with 39 points and is having a solid season focused on results. After playing 20 matches, they have 11 wins, 6 draws, and 3 losses, with a goal difference of 32:16, showing strong defense and controlled offense. Their form is positive, with a series of wins and narrow results.
Offensively, Juventus plays smart, with patient attacks and a strong finish, while their defense is disciplined and well-organized. Yildiz is the standout attacker, with Vlahovic and David as important options. Away from home, they have five wins, two draws, and three losses in 10 matches, with a goal difference of 12:8. Their style is pragmatic and results-oriented.
Cagliari will defend deeply and look for chances from set pieces, while Juventus will control the game and the pace. A tactical duel with few goals and an advantage for the visitors is expected.
2 (Juventus to Win)
Predicted CS: 0:1
:
:
vs 
Parma vs Genoa
Parma is currently in 14th place with 22 points and is fighting hard to stay out of the relegation zone. After playing 20 matches, they have five wins, seven draws, and eight losses, with a goal difference of 14:22, which clearly shows issues with their offensive efficiency and cautious approach. Their form is inconsistent, featuring a few useful draws but also losses against stronger opponents.
Offensively, Parma creates very few clear chances and relies on individual efforts, while their defense is relatively organized but often under pressure. Pellegrino is the most effective player up front, with Bernabe being an important link in the midfield. At home, they have two wins, three draws, and five losses in 10 matches, with a goal difference of 7:13, which doesn’t give them a strong advantage. Their style of play is defensive and focused on results.
Genoa is currently in 15th place with 19 points and is also fighting to stay in the league. After playing 20 matches, they have 4 wins, 7 draws, and 9 losses, with a goal difference of 22:29. This shows they have a bit more offensive potential, but their defense is unstable. Their form is inconsistent, with wins at home but poor performances away.
Offensively, Genoa plays directly and physically, focusing on crosses and set pieces, while their defense tends to leave gaps between the lines. Colombo is the top scorer, with Ostigard and Malinovskyi being important players. Away from home, they have two wins, three draws, and 4 losses in 9 matches, with a goal difference of 13:16. Their style is combative and reactive.
Both teams are entering the match cautiously, focusing on the result and minimizing risks. A closed match with few chances is expected.
0-2 (Under 2.5)
Predicted CS: 1:1
:
:
vs 
Bologna vs Fiorentina
Bologna is currently in 8th place with 30 points earned and has a season that shows clear stability in the middle of the table. After playing 20 matches, they have 8 wins, 6 draws, and 6 losses, with a goal difference of 26:20, indicating solid defense and decent offensive efficiency. Their form is variable, with a mix of draws and losses, but overall they look competitive against teams of similar rank.
Offensively, Bologna plays in an organized and patient manner, maintaining a good balance between the wings and central positions, while their defense is compact and hard to break through at home. Orsolini is their biggest offensive threat, with Castro and Cambiaghi providing important support. At home, they have 4 wins, 2 draws, and 3 losses in 9 matches, with a goal difference of 11:8. Their style of play is structured and tactically disciplined.
Fiorentina is currently in 18th place with 14 points and is having a tough season filled with scoring issues. After playing 20 matches, they have two wins, 8 draws, and 10 losses, with a goal difference of 21:31, which shows serious defensive weaknesses and a lack of consistency. Their form is unstable, with rare victories and frequent drops, especially when playing away.
Offensively, Fiorentina relies on individual talent, but they struggle to create clear chances from positional attacks, while their defense often leaves gaps between the lines. Kean and Mandragora are the most effective players, with Gudmundsson providing creative support. They are still winless away from home, with five draws and five losses in 10 matches, and a goal difference of 7:16. Their style is reactive and cautious.
Bologna plays more controlled and organized at home, while Fiorentina will look to earn points through a closed game and transitions. A tactical duel with few chances and an advantage for the home team is expected.
1X (Bologna to Win or Draw)
Predicted CS: 1:0
:
:
vs 
Torino vs AS Roma
Torino is currently in 12th place with 23 points and has a season full of ups and downs. After playing 20 matches, they have 6 wins, 5 draws, and 9 losses, with a goal difference of 21:32, which shows they struggle with scoring and have defensive issues at times. Their form is shaky, with some good performances at home, but also heavy losses against stronger opponents.
Offensively, Torino relies on direct play and physical battles, but they find it hard to maintain consistent pressure during positional attacks, while their defense can falter under pressure. Vlasic and Simeone are the most dangerous players up front, with Adams as an additional option. At home, they have three wins, two draws, and five losses in 10 matches, with a goal difference of 11:18. Their style is combative and reactive.
AS Roma is currently in 5th place with 39 points and is having a strong season, clearly fighting for a spot in next season’s Champions League. After playing 20 matches, they have 13 wins, no draws, and 7 losses, with a goal difference of 24:12, highlighting their solid defense and effective approach. Their form is good, with a series of victories and a controlled style of play.
Offensively, Roma plays smart, with quick transitions and efficient finishing, while their defense remains compact and disciplined. Soule is a key creative threat, with Ferguson and Dovbyk as important scorers. On the road, they have 6 wins and 4 losses in 10 matches, with a goal difference of 11:7. Their style of play is results-oriented.
Torino will try to slow down the pace and play physically, while Roma will control the game through discipline and transitions. A tactical duel is expected, with a slight advantage for the visitors.
GG (BTTS-Yes)
Predicted CS: 1:2
:
:
vs 
AC Milan vs Lecce
AC Milan is currently in 2nd place with 43 points and is having a season where they are consistently fighting for the top. After playing 20 matches, they have 12 wins, 7 draws, and 1 loss, with a goal difference of 30:15, showing a strong defense and enough offensive effectiveness. Their form is solid, with a streak of matches without a loss and a controlled approach, even though they often win by a small margin.
Offensively, Milan plays in an organized way, building up gradually and focusing on the wing positions, while their defense is compact and disciplined. Pulisic is their most effective scorer, with Leao being the main threat on the left side and Nkunku as an additional offensive option. At home, they have 6 wins, 3 draws, and 1 loss in 10 matches, with a goal difference of 16:9, which gives them a clear advantage.
Lecce is currently in 17th place with 17 points and is just above the relegation zone. After playing 20 matches, they have 4 wins, 5 draws, and 11 losses, with a goal difference of 13:28, which shows serious offensive limitations and an unstable defense. Their form is negative, with a series of losses and a low number of goals scored recently.
Offensively, Lecce relies on set pieces and individual attempts, but struggles to create chances from open play, while their defense often breaks under continuous pressure. Berisha, Banda, and Coulibaly are the standout players, but they lack sufficient support. Away from home, they have two wins, two draws, and five losses in 9 matches, with a goal difference of 6:13. Their style is defensive and reactive.
Milan will control the game through possession and patient pressure, while Lecce will defend deep and look for a rare counterattack. A one-sided match is expected with the home team dominating.
1 & T1 2+ (Milan to Win & Over1.5)
Predicted CS: 2:0
:
:
vs 
Cremonese vs Verona
Cremonese is currently in 13th place with 22 points and has had a season with mixed results, but they are doing okay in the middle of the table. After playing 20 matches, they have five wins, seven draws, and eight losses, with a goal difference of 20:28, which shows they have a decent offense but some defensive weaknesses. Their form is unstable, with draws and narrow losses against stronger opponents.
Offensively, Cremonese relies on direct play and experience in attack, but they often struggle to create chances from set plays, while their defense can crack under continuous pressure. Bonazzoli and Vardy are their main attacking options, with Baschirotto being an important figure in the defense. At home, they have two wins, four draws, and three losses in nine matches, with a goal difference of 11:13, indicating moderate stability. Their style of play is cautious and physical.
Verona is currently in 20th place with 13 points and is deeply involved in the fight for survival. After playing 20 matches, they have two wins, 7 draws, and 11 losses, with a goal difference of 15:31, which clearly shows serious issues in both offense and defense. Their form is negative, with more losses in recent rounds and a lack of confidence.
Offensively, Verona relies on individual efforts and counter-attacks, but they create very few clear chances, while their defense often leaves gaps between the lines. Orban is their most effective scorer, with Giovane and Belghali providing support, but they lack consistency. On the road, they have only one win, 4 draws, and five losses in 10 matches, with a goal difference of 7:18. Their style is defensive and reactive.
Cremonese will take the initiative and have more possession, while Verona will defend deeply and wait for a chance to counter. A close match with few chances and a high tactical focus is expected.
0-2 (Under 2.5)
Predicted CS: 1:0
:
:
vs 
Lazio vs Como
Lazio is currently in 9th place with 28 points and has had a season with ups and downs, but they are in a solid position in the middle of the table. After playing 20 matches, they have 7 wins, 7 draws, and 6 losses, with a goal difference of 21:16, indicating a disciplined defense and a moderate offense. Their form is variable, with more draws and close results.
Offensively, Lazio plays patiently, focusing on control and building up gradually, while their defense is compact and well-organized. Zaccagni and Cancellieri bring creativity and energy, with Castellanos as an option for finishing. At home, they have 4 wins, 4 draws, and 2 losses in 10 matches, with a goal difference of 15:9, which gives them a slight advantage. Their style is controlled and tactically disciplined.
Como is in 6th place with 34 points and has gone without a loss, but last round they were defeated by AC Milan at home. After playing 20 matches, they have 9 wins, 7 draws, and 4 losses, with a goal difference of 28:16, showing great defensive stability and efficiency. Their form is good, with a series of positive results and high confidence.
Offensively, Como plays in an organized and direct way, with quick transitions, while their defense is compact and hard to break through. Paz is a key creator and scorer, with Douvikas as the main threat in attack and Addai providing support. Away from home, they have 4 wins, 3 draws, and 3 losses in 10 matches, with a goal difference of 14:9. Their style is pragmatic and results-oriented.
Lazio will try to control the game through possession, while Como will look for results through discipline and quick transitions. A tactical duel with few chances and a balanced flow is expected.
X2 (Draw or Como to Win)
Predicted CS: 1:1
Published:
:
:
Context from Serie A Matchweek 20 predictions, together with the upcoming Serie A Matchweek 22 predictions, provides a clear progression across rounds.