Serie A Matchweek 22 of the 2025/26 season (January 23–26) comes at a stage where momentum starts to matter even more, and small details can swing tight games. With title contenders focused on consistency and chasing sides hunting points for Europe, squad management and in-game adjustments should be decisive. Expect several fixtures to be influenced by pressing intensity, transitions after turnovers, and set-piece execution. The final stretch of matches could hinge on composure under pressure, bench impact, and how well teams protect leads or respond when falling behind. Within the current round of Serie A predictions, matches like this are evaluated through structure, momentum, and squad availability.
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Inter vs Pisa
Inter is in first place with 49 points and is the top favorite for the title. After 21 matches, they have 16 wins, 4 draws, and 4 losses, with a goal difference of 44:17, which clearly shows their dominant quality. Their form is excellent, with a series of solid victories and control of the pace in most games.
Offensively, they play in a varied and effective way, with a strong finishing ability and constant pressure, while the defense is compact and disciplined. Lautaro Martinez is the main attacking threat, with Calhanoglu and Thuram providing key support. At home, they have 8 wins, 3 draws, and 2 losses in 11 matches, with a goal difference of 27:8. Their style is dominant, controlling, and tactically mature.
In the group stage of the league, the champions were outplayed by Arsenal at home with a score of 1:3.
Pisa is currently in 19th place with 14 points and is in a serious fight for survival. After 21 matches, they have only one win, 11 draws, and 9 losses, with a goal difference of 16:31, which shows they have big problems in scoring and a limited offensive capacity. Their form is weak, with few positive moments and difficulties in maintaining results.
Offensively, they create very few chances and rely on individual efforts, while their defense is often under constant pressure. Moreo and Nzola are the most effective players up front, with Tramoni as an additional option. They have not won a single match away from home, with 7 draws and 3 losses, and a goal difference of 14:20. Their style is defensive and reactive.
Inter will take full control from the start and impose a high tempo, while Pisa will defend deeply and try to limit the loss. The gap in quality and form is huge.
1 & T1 2+ (Inter to Win & Over1.5)
Predicted CS: 3:0
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Como vs Torino
Como is in 6th place with 37 points and is having a great season with real hopes for the top of the table. After playing 20 matches, they have 10 wins, 7 draws, and 4 losses, with a goal difference of 28:16, showing that they have a very well-balanced team. Their form is positive, with a series of good results and a high level of confidence.
Offensively, they play patiently and organized, with good ball movement and control of the pace, while the defense is compact and rarely allows clear chances. Paz and Douvikas are key in attack, with Adlai as a useful option from the sidelines. At home, they have five wins, 4 draws, and only one loss in 10 matches, which is a strong performance. Their style is structured and controlling.
Torino is currently in 14th place with 23 points and is having an unstable season with frequent ups and downs. After playing 21 matches, they have 6 wins, 5 draws, and 10 losses, with a goal difference of 21:34, indicating serious issues with scoring and a weak offensive performance. Their form is inconsistent, making it hard to maintain continuity.
Offensively, they create very few chances from open play and often rely on individual efforts, while their defense tends to struggle under prolonged pressure. Vlasic and Simeone are the most effective players up front, with Adams as an additional option. Away from home, they have three wins, three draws, and four losses, showing a lack of stability. Their style is cautious and reactive.
Como will try to control the game through possession and rhythm, while Torino will focus on a solid defense and set pieces. Playing at home and having better form gives the host an advantage.
1 (Como to Win)
Predicted CS: 1:0
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Fiorentina vs Cagliari
Fiorentina is currently in 17th place with 17 points and is having a disappointing season, facing serious pressure in the fight for survival. After playing 21 matches, they have three wins, eight draws, and ten losses, with a goal difference of 23:32, indicating issues with scoring and a lack of stability in defense. Their form is inconsistent, showing a few positive results but lacking continuity.
They create chances offensively, but struggle to finish their plays, while the defense often falters at crucial moments. Mandragora and Kean are the most effective players up front, with Gudmundsson providing creative support. At home, they have two wins, three draws, and five losses in ten matches, which does not inspire confidence. Their style is possession-oriented, but they have low intensity in the final third.
Cagliari is currently in 15th place with 22 points and is fighting to avoid the lower part of the table. After 21 matches, they have five wins, seven draws, and nine losses, with a goal difference of 22:30, which shows limited offensive ability and a vulnerable defense. Their form is unstable, with frequent drops and difficulties when playing away.
Offensively, they rely on individual solutions and set pieces, while their defense can be passive under pressure. Esposito and Borriello are the most dangerous in attack, with Gaetano providing important support. On the road, they have two wins, four draws, and five losses, and they are not stable enough. Their style is cautious and reactive.
Fiorentina will try to impose possession and initiative at home, while Cagliari will play defensively and wait for chances from transitions. The match seems evenly matched, with a slight advantage for the home team due to playing on their own turf.
1X (Fiorentina to Win or Draw)
Predicted CS: 2:1
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Lecce vs Lazio
Lecce is currently in 18th place with 17 points and is seriously at risk of relegation. After playing 21 matches, they have 4 wins, 5 draws, and 12 losses, with a goal difference of 13:29, which shows they have major issues in offense and a weak attacking performance. Their form is poor, with a string of losses and struggles to create chances against stronger opponents.
They play cautiously in attack, taking few shots on goal and relying heavily on set pieces, while their defense is often under constant pressure and tends to give in during the second half. Banda, Berisha, and Coulibaly are the most notable players, but their impact is limited. At home, they have two wins, three draws, and 6 losses, lacking real confidence. Their style is defensive and reactive.
Lazio is currently in 9th place with 28 points and is having a season that is below expectations, but there is potential for improvement. After playing 20 matches, they have 7 wins, 7 draws, and 7 losses, with a goal difference of 21:19, indicating a strong defense and a limited but effective offense. Their form is inconsistent, showing better performances against weaker opponents.
They play offensively in an organized and patient manner, controlling the tempo, while their defense is compact and tactically disciplined. Zaccagni and Castellanos are the main threats up front, with Luis Alberto providing creative support. In away games, they have three wins, three draws, and four losses, showing a solid but not dominant performance. Their style is balanced and controlling.
Lecce will try to defend deeply and slow down the pace, while Lazio will take the initiative through possession and discipline. We expect a tough match with few goals.
0-2 (Under 2.5)
Predicted CS: 0:1
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Sassuolo vs Cremonese
Sassuolo is currently in 11th place with 23 points and is having a season with big ups and downs. After playing 21 matches, they have 6 wins, 5 draws, and 10 losses, with a goal difference of 23:28. This shows they have offensive potential but also serious defensive weaknesses. Their form is weak, with a series of losses in the last few games affecting their confidence.
Offensively, they play with skill and individual talent, but their finishing is inconsistent, while their defense often leaves too much space between the lines. Berardi is the main creative and attacking player, with Pinamonti and Lauriente providing support. At home, they have three wins, two draws, and five losses, which doesn’t bring much certainty. Their style is open and risky.
Cremonese is currently in 12th place with 23 points and is fighting for stability in the middle of the table. After playing 21 matches, they have five wins, eight draws, and eight losses, with a goal difference of 20:28. This shows they have a limited offensive performance and a solid, but not strong, defense. Their form is inconsistent, with mixed results and issues when playing away.
Offensively, they rely heavily on Bonazzoli and Vardy, while the rest of the team rarely contributes to scoring. Defensively, they are organized but can struggle under continuous pressure. When playing away, they have three wins, three draws, and five losses. Their style is cautious and focused on results.
Sassuolo will try to set the pace and be offensive at home, but their unstable form gives Cremonese a chance to use their organized approach. The match seems evenly matched, with a possibility of sharing points.
X (Draw)
Predicted CS: 1:1
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Atalanta vs Parma
Atalanta is currently in 7th place with 32 points and is actively competing for European spots. After playing 21 matches, they have 8 wins, 8 draws, and 5 losses, with a goal difference of 26:20, showing a solid balance between offense and defense. Their form is stable, with consistent results and few losses.
They play offensively with high intensity, quick transitions, and varied attacks, while their defense is compact and well-organized.
Scamacca and Krstovic are the main attacking threats, with De Ketelaere providing creative support. At home, they have 5 wins, 4 draws, and 2 losses in 11 matches, giving them a clear advantage. Their style is aggressive, press-oriented, and tactically clear.
In the group stage of the Champions League, they were outplayed by Ath Bilbao and lost 2:3 in front of their home crowd.
Parma is currently in 13th place with 23 points and has a season with some ups and downs. After playing 21 matches, they have five wins, eight draws, and eight losses, with a goal difference of 14:22, which shows they have a limited attacking ability and a cautious approach. Their form is inconsistent, with frequent draws and struggles to establish a rhythm.
Offensively, they create very few chances from open play and rely on individual moments, while their defense is generally disciplined but tends to crack under pressure. Pellegrino is the most effective forward, with Bernabe being an important option from the bench. Away from home, they have three wins, four draws, and three losses, showing a solid but not dominant performance. Their style is defensive and reactive.
Atalanta will impose the pace and apply constant pressure, while Parma will try to defend compactly and slow down the tempo. The quality, form, and home advantage are clearly in favor of the hosts.
1 (Atalanta to Win)
Predicted CS: 2:0
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Genoa vs Bologna
Genoa is currently in 16th place with 20 points and is fighting to avoid relegation, just three points above the drop zone. After playing 21 matches, they have 4 wins, 8 draws, and 9 losses, with a goal difference of 22:29, showing limited effectiveness and a frequent lack of control in their games. Their form is unstable, with many draws and difficulties in closing out matches in their favor.
Offensively, they create very few clear chances and often rely on individual efforts, while their defense can be vulnerable under continuous pressure. Colombo is the most effective forward, with Ostigard and Malinovskyi being key players in the midfield. At home, they have two wins, 4 draws, and five losses in 11 matches, which does not provide much confidence. Their style is cautious and reactive.
Bologna is currently in 8th place with 30 points and is having a solid season in the middle of the table. They still have a chance to qualify for some European competitions. After playing 21 matches, they have 8 wins, 6 draws, and 7 losses, with a goal difference of 30:24, showing a balanced relationship between attack and defense. Their form is variable, but they have a clear attacking identity and more stability than the home team.
They play offensively in a direct and aggressive manner, with good execution, while their defense is generally organized, although it can sometimes falter when playing away. Orsolini is the main attacking threat, with Castro and Odgaard providing strong support. On the road, they have 4 wins, 4 draws, and 3 losses, which is a solid performance. Their style is proactive and dynamic.
In the group stage of the Europa League, they drew with Celtic at home with a score of 2:2.
Genoa will try to take advantage of their need for points and the home field, but Bologna has greater quality and a clearer attacking plan. We expect a close match with a slight advantage for the guests.
X2 (Bologna or Draw)
Predicted CS: 1:1
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Juventus vs Napoli
Juventus is currently in 5th place with 39 points and is competing for a spot in the Champions League. After playing 21 matches, they have 11 wins, 6 draws, and 4 losses, with a goal difference of 32:17, showing a solid defense and moderate effectiveness. Their form is stable with several wins in the recent rounds, although there are occasional fluctuations in their pace.
Offensively, Juventus plays smartly, focusing on control and gradually building their attacks, while their defense is compact and well-organized. Yıldız is a key creative player, supported by David. At home, they have 6 wins and 4 draws in 10 matches, with a goal difference of 20:8, which brings significant stability. Their style is disciplined, tactically mature, and pragmatic.
In the group stage of the Champions League, they easily defeated Benfica 2:0 at home.
Napoli is currently in 3rd place with 43 points and is directly competing for the title, having only 4 points more than today’s opponent. After 21 matches, they have recorded 13 wins, 4 draws, and 4 losses, with a goal difference of 31:17, indicating a balanced team with quality in both phases. Their form is good, with a series of positive results and high confidence.
Offensively, Napoli plays fast and direct, with strong transitions and dynamics between the lines, while their defense is stable and aggressive in duels. Hojlund is the main attacking threat, with McTominay and Anguissa providing key support from the midfield. Away from home, they have 6 wins, 1 draw, and 4 losses in 11 matches, with a goal difference of 14:9, showing solid competitiveness. Their style is intense and vertical.
In the group stage of the Champions League, they drew away against FC Copenhagen with a score of 1:1.
Juventus will try to control the midfield and slow down the game, while Napoli will press with quick transitions and an aggressive pace. A tactical and evenly matched derby is expected, with a low number of goals.
0-2 (Under 2.5)
Predicted CS: 1:1
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AS Roma vs AC Milan
AS Roma is currently in 4th place with 42 points and is firmly in the race for a spot in the Champions League. After playing 21 matches, they have 14 wins and 7 losses, with a goal difference of 26:12, highlighting their strong defensive stability. Their form is good, with a series of solid victories and a clear focus on results.
Offensively, they don’t play with high risk, but they are effective in crucial moments, while their defense remains compact and disciplined. Dybala brings creativity and control between the lines, with Soule and Dovbyk posing a direct threat up front. At home, they have 7 wins and three draws in 10 matches, which is a significant advantage. Their style is pragmatic, with a clear tactical structure.
In the group stage of the Europa League, they defeated Stuttgart at home with a score of 2:0.
AC Milan is currently in 2nd place with 46 points and is having a solid season at the top, just three points behind first-place Inter. After 21 matches, they have 13 wins, 7 draws, and only 1 loss, with a goal difference of 34:16, showing a strong offense and a reliable defense. Their form is steady, consistently earning points.
They play offensively with speed and verticality, focusing on wings and transitions, while their defense is organized and well-balanced. Pulisic and Leao are the main attackers, with Nkunku as an additional option in between the lines. In away games, they have 6 wins and 4 draws in 10 matches, remaining unbeaten. Their style is proactive and dynamic.
Roma will try to control the game through structure and discipline, while Milan will look for pace and directness. We expect at least one goal from both sides.
GG (BTTS-Yes)
Predicted CS: 1:1
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Verona vs Udinese
Verona is currently in 20th place with 14 points and is in a really tough spot in the fight for survival. After playing 21 matches, they have two wins, 8 draws, and 11 losses, with a goal difference of 17:34, which clearly shows serious defensive weaknesses and not enough effectiveness in attack. Their form is very weak, with several consecutive losses and trouble maintaining stability throughout the 90 minutes.
Offensively, they create very few chances and often rely on individual efforts, while the defense is under constant pressure and makes mistakes at crucial moments. Orban is the most effective forward, with Giovane and Belghali as additional options, but they lack sufficient support from the midfield. At home, they have one win, three draws, and six losses in 10 matches, which doesn’t really give them an advantage. Their style of play is defensive and reactive.
Udinese is currently in 10th place with 26 points and is having a fairly stable season in the middle of the table. After playing 21 matches, they have 7 wins, 5 draws, and 9 losses, with a goal difference of 22:33, which shows that while they can be dangerous in attack, their defense isn’t always reliable. Their form is inconsistent, with mixed results and fluctuations, especially when playing away.
They play offensively in a direct and physical manner, focusing heavily on transitions, while defensively they can struggle under prolonged pressure. Davis and Zaniolo are their main attacking threats, with Ekkelenkamp providing important support from the background. On away turf, they have 4 wins, 1 draw, and 5 losses, which is a decent performance. Their style is balanced, emphasizing duels and quick counterattacks.
Verona will try to play defensively and earn points through hard work, while Udinese has more quality and options in attack. We expect the visitors to control the game and not leave empty-handed in this match.
X2 (Draw or Udinese to Win)
Predicted CS: 0:1
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This matchweek can be viewed alongside insights from Serie A Matchweek 21 predictions and the forthcoming coverage in Serie A Matchweek 23 predictions